Choosing a spin-lock transmitter position which minimizes HOHAHA distortions of ROESY spectra. Observation of a correlation-time dependence of frequency offset

被引:5
作者
Chan, TM
Dalgarno, DC
Prestegard, JH
Evans, CA
机构
[1] SCHERING PLOUGH CORP, RES INST, KENILWORTH, NJ 07033 USA
[2] YALE UNIV, DEPT CHEM, NEW HAVEN, CT USA
关键词
D O I
10.1006/jmre.1997.1162
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A technique for reliably selecting a transmitter position for rotating-frame NOE experiments which minimize scalar coupling artifacts is described. The technique makes use of the COSY spectrum of the molecule in question. The method is illustrated by application to thiostrepton, an antibiotic of molecular weight 1665. For an individual compound, the range of transmitter settings over which HOHAHA distortions are observed is found to depend on the molecular correlation time of the compound under study. The origin of this effect is discussed in terms of rotating-frame relaxation during the spin-lock period. (C) 1997 Academic Press.
引用
收藏
页码:183 / 186
页数:4
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