Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic Mannich-type reactions and the stereoselective synthesis of azetidines

被引：60

作者：

Morimoto, Hiroyuki ^{[1
]}

Wiedemann, Seat H. ^{[1
]}

Yamaguchi, Akitake ^{[1
]}

Harada, Shinji ^{[1
]}

Chen, Zhihua ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 19期

关键词：

asymmetric catalysis; azetidines; diastereoselectivity; Mannich reaction; trichloromethyl ketones;

D O I：

10.1002/anie.200600227

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon-carbon bond-forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG = protecting group. (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3146 / 3150

页数：5

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