Cytochrome P450 structures and their substrate interactions

被引：11

作者：

Lewis, DFV ^{[1
]}

Ito, Y

Goldfarb, PS

机构：

[1] Univ Surrey, Sch Biomed & Mol Sci, Guildford GU2 7XH, Surrey, England

[2] Kyushu Inst Technol, Dept Biosci & Bioinformat, Fukuoka, Japan

来源：

DRUG DEVELOPMENT RESEARCH | 2005年 / 66卷 / 01期

关键词：

cytochromes P450 structures; substrate binding; new chemical entity;

D O I：

10.1002/ddr.20040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure and function of cytochrome 13450 (CYP) enzymes is reviewed in the context of the currently available high-resolution crystal structures and homology models in the public domain. Two human P450 enzymes from the CYP2C subfamily (CYP2C8 and CYP2C9) have been resolved crystallographically with good agreement with the results of molecular modelling based on the CYP2C5 template structure. Aspects of the P450 structures that bear on the function and catalytic activity of the enzymes, especially in relation to the binding of substrates, redox partners, and oxygen, are discussed in the light Of Current evidence.

引用

页码：19 / 24

页数：6

共 31 条

[1]

ACHAKOV AI, 1990, CYTOCHROME P459 ACTI

[2] Cytochromes P450 and metabolism of xenobiotics [J].

Anzenbacher, P ;

Anzenbacherová, E .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (5-6) :737-747

[3] Cytochrome P450: Structure, function, and generation of reactive oxygen species [J].

Bernhardt, R .

REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, VOL 127, 1996, 127 :137-221

[4]

de Montellano P. R. O., 2005, CYTOCHROME P450 STRU

[5]

DEMONTELLANO PRO, 1986, CYTOCHROME P450

[6]

DEMONTELLANO PRO, 1995, CYTOCHROME P450

[7] Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis [J].

Domanski, TL ;

Halpert, JR .

CURRENT DRUG METABOLISM, 2001, 2 (02) :117-137

[8]

Gibson GG., 2001, Introduction to Drug Metabolism

[9]

Ioannides C., 2002, ENZYME SYSTEMS METAB, P33

[10]

Ioannides C., 1996, CYTOCHROMES P450 MET

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