Blocking autophagy to starve pancreatic cancer

被引:23
作者
Bryant, Kirsten L. [1 ]
Der, Channing J. [1 ]
机构
[1] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA
关键词
D O I
10.1038/s41580-019-0120-8
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer. © 2019, Springer Nature Limited.
引用
收藏
页码:265 / 265
页数:1
相关论文
共 5 条
[1]
Bryant K.L., Et al., Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer, Nat. Med., (2019)
[2]
Kinsey C.G., Et al., Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers, Nat. Med., (2019)
[3]
Yang S., Et al., Pancreatic cancers require autophagy for tumor growth, Genes Dev., 25, pp. 717-729, (2011)
[4]
Yang A., Et al., Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations, Cancer Discov., 4, pp. 905-913, (2014)
[5]
Dikic I., Elazar Z., Mechanism and medical implications of mammalian autophagy, Nat. Rev. Mol. Cell Biol., 19, pp. 349-364, (2018)