New, diastereoselective synthesis of 1-alkyl-5-alkylidene-3-methylidenepyrrolidin-2-ones

被引：15

作者：

Albrecht, A ^{[1
]}

Kedzia, J ^{[1
]}

Koszuk, JF ^{[1
]}

Warzycha, E ^{[1
]}

Janecki, T ^{[1
]}

机构：

[1] Tech Univ Lodz, Inst Organ Chem, PL-90924 Lodz, Poland

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 14期

关键词：

pyrrolidinones; Horner-Wadsworth-Emmons olefination; alpha-methylidene-gamma-lactams;

D O I：

10.1016/j.tetlet.2006.02.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective synthesis of 1-alkyl-5-alkylidene-3-methylidenepyrrolidin-2-ones was readily accomplished in a two-step reaction sequence consisting of the reaction of 2-diethoxyphosphoryl-4-oxoalkanoates with amines followed by Horner-Wadsworth-Emmons olefination of formaldehyde using the intermediate 1-alkyl-5-alkylidene-3-diethoxyphosphorylpyrrolidin-2-ones. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2353 / 2355

页数：3

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