Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells

被引：7

作者：

Johann, Susana ^{[1
,2
]}

Silva, Daniele L. ^{[2
]}

Martins, Cleide V. B. ^{[2
,3
]}

Zani, Carlos L. ^{[1
]}

Pizzolatti, Moacir G. ^{[4
]}

Resende, Maria A. ^{[2
]}

机构：

[1] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Quim Prod Nat, BR-30190002 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil

[3] Univ Estadual Oeste Parana, Ctr Engn & Ciencias Exatas, Toledo, PR, Brazil

[4] Univ Fed Santa Catarina, Dept Quim, Florianopolis, SC, Brazil

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2008年 / 24卷 / 11期

关键词：

anti-adhesion; antifungal; buccal epithelial cells; cytotoxic activity; Punica granatum; Schinus terebinthifolius;

D O I：

10.1007/s11274-008-9768-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Plants are known to produce a plethora of secondary metabolites which are recognized as a useful source of new drugs or drug leads. Extracts and fractions of Schinus terebinthifolius Raddi (Anacardiaceae), Piper regnellii C.D.C. (Piperaceae), Rumex acetosa L. (Polygonaceae), and Punica granatum L. (Punicaceae) were assessed for their antifungal activity against eight clinical isolates of C. albicans. They were also evaluated for their effect on the adhesion of these C. albicans isolates to buccal epithelial cells (BECs). The ethyl acetate fraction from the leaves of S. terebinthifolius showed promising activity, inhibiting the growth of three C. albicans isolates at 7.8 mu g ml(-1) and significantly inhibiting their adhesion to BEC at 15 mu g ml(-1). In addition, this fraction did not show cytotoxic activity against murine macrophages. The results show the potential of the plant extracts studied as a source of new antifungal compounds. Further studies are necessary for isolation and characterization of the active compounds of these plants.

引用

页码：2459 / 2464

页数：6

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