Multichannel time-resolved tissue oximeter for functional imaging of the brain

被引：17

作者：

Contini, D ^{[1
]}

Torricelli, A

Pifferi, A

Spinelli, L

Taroni, P

Quaresima, V

Ferrari, M

Cubeddu, R

机构：

[1] Politecn Milan, Dipartimento Fis, ULTRAS CNR INFM, I-20133 Milan, Italy

[2] Politecn Milan, Dipartimento Fis, IFN CNR, I-20133 Milan, Italy

[3] Univ Aquila, Dept Biomed Sci & Technol, I-67100 Laquila, Italy

[4] Univ Aquila, Interdept Ctr Sports Sci, I-67100 Laquila, Italy

来源：

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT | 2006年 / 55卷 / 01期

关键词：

brain; laser biomedical applications; optical spectroscopy; optical tomography; pulsed lasers; random media; scattering; time-domain measurements;

D O I：

10.1109/TIM.2005.861502

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper reports the development and characterization of a novel multichannel time-resolved (TR) instrument for functional brain imaging studies. The instrument is based on picosecond diode lasers, fiber optics for light injection and delivery, a compact multianode photomultiplier, and a personal computer (PC) board for time-correlated single photon counting (TCSPC). The instrument has been characterized in terms of reproducibility among the nine sources and the 12 collection channels, linearity in the determination of optical properties (absorption and reduced scattering), and stability. Preliminary in vivo measurements were performed on volunteers to monitor the optical response to stimuli following a motor task (finger opposition, 5 Hz).

引用

页码：85 / 90

页数：6

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