Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia

被引:159
作者
Babulas, V [1 ]
Factor-Litvak, P [1 ]
Goetz, R [1 ]
Schaefer, CA [1 ]
Brown, AS [1 ]
机构
[1] Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
关键词
D O I
10.1176/appi.ajp.163.5.927
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring. Method: The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled. Results: Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness. Conclusions: Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.
引用
收藏
页码:927 / 929
页数:3
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