The Gallic Acid-Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

被引：81

作者：

Bhattacharyya, Sauvik ^{[1
]}

Ahammed, Sk Milan ^{[1
]}

Saha, Bishnu Pada ^{[1
]}

Mukherjee, Pulok K. ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Sch Nat Prod Studies, Kolkata 700032, India

来源：

AAPS PHARMSCITECH | 2013年 / 14卷 / 03期

关键词：

bioavailability; gallic acid; hepatoprotective activity; pharmacokinetic; phospholipid complex; CARBON-TETRACHLORIDE; METABOLIC-FATE; LIVER-DAMAGE; RATS; PHARMACOKINETICS; VOLUNTEERS; CATECHINS; SILIPIDE; EXTRACTS; PLASMA;

D O I：

10.1208/s12249-013-9991-8

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl4)-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl4-induced group (P<0.05 and P<0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.

引用

页码：1025 / 1033

页数：9

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