Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer

被引：44

作者：

Buijs, Manon ^{[1
]}

Vossen, Josephina A. ^{[1
]}

Geschwind, Jean-Francois H. ^{[1
]}

Ishimori, Takayoshi ^{[1
]}

Engles, James M. ^{[1
]}

Acha-Ngwodo, Obele ^{[1
]}

Wahl, Richard L. ^{[1
]}

Vali, Mustafa ^{[1
]}

机构：

[1] Russell H Morgan Dept Radiol & Radiol Sci, Div Vasc & Intervent Radiol, Baltimore, MD 21287 USA

来源：

INVESTIGATIONAL NEW DRUGS | 2009年 / 27卷 / 02期

关键词：

Breast cancer; 3-Bromopyruvate; FDG; RMT; Animal model; RABBIT VX2 TUMOR; LIVER-CANCER; INTRAARTERIAL INJECTION; MAMMARY-CARCINOMA; POTENT INHIBITOR; GLUCOSE; CELLS; THERAPY; PET; METABOLISM;

D O I：

10.1007/s10637-008-9145-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: To evaluate the anti-glycolytic effects of 3-BrPA on rats bearing RMT mammary tumors, by determining FDG uptake after intravenous administration of the therapeutic dose. Materials and Methods: Sixteen rats bearing RMT tumors were treated either with 15 mM 3-BrPA in 2.5 ml of PBS or with 2.5 ml of PBS. After treatment, all rats received FDG and were sacrificed 1 h later. Results: 3-BrPA treatment significantly decreased FDG uptake in tumors by 77% (p = 0.002). FDG uptake did not significantly decrease in normal tissues after treatment. Conclusion: Our study showed that 3-BrPA exhibits a strong anti-glycolytic effect on RMT cells implanted in rats.

引用

页码：120 / 123

页数：4

共 26 条

[1]

Impact of chemotherapy in women with metastatic breast cancer diagnosed 1990-2003 [J].