Interplay between mycobacteria and host signalling pathways

被引：302

作者：

Koul, A

Herget, T

Klebl, B

Ullrich, A

机构：

[1] Axxima Pharmaceut AG, D-81377 Munich, Germany

[2] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrmicro840

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to enhance the intracellular survival and persistence of the pathogen. The disruption of these pathways by mycobacteria causes impaired maturation of phagosomes into phagolysosomes, modulates host-cell apoptotic pathways and suppresses the host immune response. This review highlights the strategies employed by mycobacteria to subvert host-cell signalling and identifies key molecules involved in these processes that might serve as potential targets for new anti mycobacterial therapies.

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收藏

页码：189 / 202

页数：14

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