Attenuation of morphine withdrawal signs by the GABAB receptor agonist baclofen

被引：31

作者：

Bexis, S

Ong, J ^{[1
]}

White, J

机构：

[1] Univ Adelaide, Dept Anaesthesia & Intens Care, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Sch Med, Dept Clin & Expt Pharmacol, Adelaide, SA 5005, Australia

[3] Drug & Alcohol Serv Council, Adelaide, SA, Australia

来源：

LIFE SCIENCES | 2001年 / 70卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

baclofen; morphine-dependence; morphine withdrawal; rat; naloxone; CGP; 46381;

D O I：

10.1016/S0024-3205(01)01485-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study examined the effect of the gamma -aminobutyric acid(B) (GABA(B)) receptor agonist, baclofen on naloxone-induced withdrawal signs in morphine-dependent rats and modification by the antagonist, 3-aminopropyl-cyclohexylmethylphosphinic acid (CGP 46381). Morphine was administered via mini-osmotic pumps for 7 days to induce physical dependence. Baclofen (20 mg kg(-1)) decreased stereotyped head movements, chewing, chatter, ptosis and body weight loss, induced by naloxone (10 ing kg(-1)) in morphine-dependent rats. CGP 46381 (20 ing kg(-1)) reversed the effects exerted by baclofen on stereotyped head movements, ptosis, and weight loss and partially reversed the effect of baclofen on chewing. It can be concluded that baclofen has some potential in the treatment of opioid withdrawal and that GABAB receptors may be implicated in such a withdrawal. (C) 2001 Elsevier Science Inc. All ri-hts reserved.

引用

页码：395 / 401

页数：7

共 20 条

[1] CORTICAL ACETYLCHOLINE-RELEASE IS INCREASED AND GAMMA-AMINOBUTYRIC-ACID OUTFLOW IS REDUCED DURING MORPHINE-WITHDRAWAL [J].