Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

被引：273

作者：

Bosveld, Floris ^{[1
]}

Bonnet, Isabelle ^{[1
]}

Guirao, Boris ^{[1
]}

Tlili, Sham ^{[1
]}

Wang, Zhimin ^{[1
]}

Petitalot, Ambre ^{[1
]}

Marchand, Raphael ^{[1
]}

Bardet, Pierre-Luc ^{[1
]}

Marcq, Philippe ^{[2
]}

Graner, Francois ^{[1
]}

Bellaiche, Yohanns ^{[1
]}

机构：

[1] Inst Curie, CNRS, Polar Div & Morphogenesis Team, INSERM,UMR 3215,U934, F-75248 Paris 05, France

[2] Univ Paris 06, Inst Curie, Lab Phys Chim Curie, CNRS,UMR 168, F-75248 Paris 05, France

来源：

SCIENCE | 2012年 / 336卷 / 6082期

基金：

欧洲研究理事会;

关键词：

FAT; DROSOPHILA; GROWTH; DACHS; EXPRESSION; DIVISIONS; AFFINITY; ENCODES; MYOSIN; MEMBER;

D O I：

10.1126/science.1221071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During animal development, several planar cell polarity (PCP) pathways control tissue shape by coordinating collective cell behavior. Here, we characterize by means of multiscale imaging epithelium morphogenesis in the Drosophila dorsal thorax and show how the Fat/Dachsous/Four-jointed PCP pathway controls morphogenesis. We found that the proto-cadherin Dachsous is polarized within a domain of its tissue-wide expression gradient. Furthermore, Dachsous polarizes the myosin Dachs, which in turn promotes anisotropy of junction tension. By combining physical modeling with quantitative image analyses, we determined that this tension anisotropy defines the pattern of local tissue contraction that contributes to shaping the epithelium mainly via oriented cell rearrangements. Our results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis.

引用

页码：724 / 727

页数：4

共 23 条

[1] Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila [J].