The nucleolus and herpesviral usurpation

被引:8
作者
Ni, Liwen [1 ]
Wang, Shuai [1 ]
Zheng, Chunfu [1 ]
机构
[1] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Mol Virol & Viral Immunol Res Grp, Wuhan 430071, Peoples R China
关键词
SIMPLEX-VIRUS TYPE-1; NUCLEAR EXPORT; LOCALIZATION SIGNALS; SUBCELLULAR-LOCALIZATION; PROTEOMICS ANALYSIS; PROTEIN; CELL; IDENTIFICATION; REV; B23;
D O I
10.1099/jmm.0.045963-0
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
The nucleolus is a distinct subnuclear compartment known as the site for ribosome biogenesis in eukaryotes. Consequently, the nucleolus is also proposed to function in cell-cycle control, stress sensing and senescence, as well as in viral infection. An increasing number of viral proteins have been found to localize to the nucleolus. In this article, we review the current understanding of the functions of the nucleolus, the molecular mechanism of cellular and viral protein targeting to the nucleolus and the functional roles of the nucleolus during viral infection with a specific focus on the herpesvirus family.
引用
收藏
页码:1637 / 1643
页数:7
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