Immunoglobulin Replacement Therapy in Children

被引：45

作者：

Garcia-Lloret, Maria ^{[1
]}

McGhee, Sean ^{[1
]}

Chatila, Talal A. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Rheumatol Allergy & Immunol, Dept Pediat, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2008年 / 28卷 / 04期

关键词：

Intravenous immunoglobulin therapy; Subcutaneous immunoglobulin therapy; Primary immunodeficiency diseases;

D O I：

10.1016/j.iac.2008.07.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The benefit of immunoglobulin (IG) replacement in primary antibody deficiencies is unquestionable. Many of these congenital disorders present early in life and this therapy is often first implemented in the young. This article focuses on the indications of IG replacement in children, with an emphasis on the specific diagnostic problems encountered in this population. Also presented is an overview of the practical aspects of IG administration in the pediatric setting, including the recognition and management of adverse reactions. Finally, the advent of subcutaneous IG, a therapeutic IG modality with the potential to have a great impact on the quality of life of children with antibody deficiencies and their families, is discussed.

引用

页码：833 / 849

页数：17

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