Molecular evidence for interspecies transmission of H3N2pM/H3N2v influenza A viruses at an Ohio agricultural fair, July 2012

被引：48

作者：

Bowman, Andrew S. ^{[1
]}

Sreevatsan, Srinand ^{[2
]}

Killian, Mary L. ^{[3
,4
]}

Page, Shannon L. ^{[5
]}

Nelson, Sarah W. ^{[1
]}

Nolting, Jacqueline M. ^{[1
]}

Cardona, Carol ^{[2
]}

Slemons, Richard D. ^{[1
]}

机构：

[1] Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USA

[2] Univ Minnesota, Coll Vet Med, Dept Vet Biomed Sci, St Paul, MN USA

[3] Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA

[4] USDA, Diagnost Virol Lab, Natl Vet Serv Labs, Anim & Plant Hlth Inspect Serv, Ames, IA 50010 USA

[5] Ohio Dept Hlth, Columbus, OH 43215 USA

来源：

EMERGING MICROBES & INFECTIONS | 2012年 / 1卷

基金：

美国国家卫生研究院;

关键词：

human H3N2v; H3N2pM; influenza; fair; swine; SWINE INFLUENZA; PANDEMIC H1N1; PIGS; HUMANS; INFECTIONS; WORKERS; PCR; SURVEILLANCE; EVOLUTION; OUTBREAK;

D O I：

10.1038/emi.2012.33

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evidence accumulating in 2011-2012 indicates that there is significant intra-and inter-species transmission of influenza A viruses at agricultural fairs, which has renewed interest in this unique human/swine interface. Six human cases of influenza A (H3N2) variant (H3N2v) virus infections were epidemiologically linked to swine exposure at fairs in the United States in 2011. In 2012, the number of H3N2v cases in the Midwest had exceeded 300 from early July to September, 2012. Prospective influenza A virus surveillance among pigs at Ohio fairs resulted in the detection of H3N2pM (H3N2 influenza A viruses containing the matrix (M) gene from the influenza A (H1N1) pdm09 virus). These H3N2pM viruses were temporally and spatially linked to several human H3N2v cases. Complete genomic analyses of these H3N2pM isolates demonstrated >99% nucleotide similarity to the H3N2v isolates recovered from human cases. Actions to mitigate the bidirectional inter-species transmission of influenza A virus between people and animals at agricultural fairs may be warranted.

引用

页数：8

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