Highly diastereo- and enantioselective direct aldol reactions in water

被引：462

作者：

Hayashi, Y ^{[1
]}

Sumiya, T ^{[1
]}

Takahashi, J ^{[1
]}

Gotoh, H ^{[1
]}

Urushima, T ^{[1
]}

Shoji, M ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 06期

关键词：

aldol reaction; asymmetric synthesis; diastereoselectivity; organocatalysis; solvent effects;

D O I：

10.1002/anie.200502488

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Going green: The synthetically very important aldol reaction can proceed in water without a metal catalyst with excellent enantioselectivity. The key to the reaction is a small, synthetic organic catalyst based on trans-hydroxyproline with a siloxy group. Thus, this method is an environmentally friendly process for the synthesis of chiral molecules. © 2006 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：958 / 961

页数：4

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