Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart

被引:96
作者
Lee, Lik Chuan [1 ,2 ]
Wall, Samuel T. [4 ]
Klepach, Doron [1 ,2 ]
Ge, Liang [1 ,2 ]
Zhang, Zhihong [1 ]
Lee, Randall J. [2 ,3 ]
Hinson, Andy
Gorman, Joseph H., III [5 ]
Gorman, Robert C. [5 ]
Guccione, Julius M. [1 ,2 ]
机构
[1] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA
[2] Univ Calif San Francisco, Dept Bioengn, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[4] Simula Res Lab, Oslo, Norway
[5] Univ Penn, Glenolden Res Lab, Gorman Cardiovasc Res Grp, Philadelphia, PA 19104 USA
关键词
Congestive heart failure; Dilated cardiomyopathy; Coronary artery bypass grafting; Left ventricular wall stress; Mathematical modeling; Magnetic resonance imaging; RESTORATION; MYOCARDIUM; SHAPE;
D O I
10.1016/j.ijcard.2013.01.003
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background: Left ventricular (LV) wall stress reduction is a cornerstone in treating heart failure. Large animal models and computer simulations indicate that adding non-contractile material to the damaged LV wall can potentially reduce myofiber stress. We sought to quantify the effects of a novel implantable hydrogel (Algisyl-LVR (TM)) treatment in combination with coronary artery bypass grafting (i.e. Algisyl-LVR (TM) + CABG) on both LV function and wall stress in heart failure patients. Methods and results: Magnetic resonance images obtained before treatment (n=3), and at 3 months (n=3) and 6 months (n=2) afterwards were used to reconstruct the LV geometry. Cardiac function was quantified using end-diastolic volume (EDV), end-systolic volume (ESV), regional wall thickness, sphericity index and regional myofiber stress computed using validated mathematical modeling. The LV became more ellipsoidal after treatment, and both EDV and ESV decreased substantially 3 months after treatment in all patients; EDV decreased from 264 +/- 91 ml to 146 +/- 86 ml and ESV decreased from 184 +/- 85 ml to 86 +/- 76 ml. Ejection fraction increased from 32 +/- 8% to 47 +/- 18% during that period. Volumetric-averaged wall thickness increased in all patients, from 1.06 +/- 0.21 cm (baseline) to 1.3 +/- 0.26 cm (3 months). These changes were accompanied by about a 35% decrease in myofiber stress at end-of-diastole and at end-of-systole. Post-treatment myofiber stress became more uniform in the LV. Conclusions: These results support the novel concept that Algisyl-LVR (TM) + CABG treatment leads to decreased myofiber stress, restored LV geometry and improved function. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:2022 / 2028
页数:7
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