Tissue engineering of biphasic joint cartilage transplants

被引：98

作者：

Kreklau, B

Sittinger, M

Mensing, MB

Voigt, C

Berger, G

Burmester, GR

Rahmanzadeh, R

Gross, U

机构：

[1] Free Univ Berlin, Inst Pathol, Med Ctr Benjamin Franklin, D-12200 Berlin, Germany

[2] Free Univ Berlin, Dept Traumatol & Reconstruct Surg, Med Ctr Benjamin Franklin, D-12200 Berlin, Germany

[3] Humboldt Univ, Dept Rheumatol, Charite, D-10117 Berlin, Germany

[4] German Rheumatism Res Ctr, D-10117 Berlin, Germany

[5] Fed Inst Mat Res & Testing BAM, Berlin, Germany

来源：

BIOMATERIALS | 1999年 / 20卷 / 18期

关键词：

calcium carbonate; resorbable polymers; cartilage; tissue engineering;

D O I：

10.1016/S0142-9612(99)00061-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In isolated posttraumatic or idiopathic joint defects the chondral layers and adjacent subchondral spongy bone are usually destructed. For regeneration we suggest the in vitro formation of a cartilage-coated biomaterial carriers (biphases) in order to fill the corresponding joint defects. In this study Biocoral(R), a natural coralline material made of calcium carbonate, and calcite, a synthetic calcium carbonate, were used as supports for the cultivation of bovine chondrocytes in a three-dimensional polymer fleece. The cell-polymer-structure was affixed to the biomaterial with a fibrin-cell-solution. The artificial cartilage formed a new matrix and fused with the underlying biomaterial. The results indicate a promising technical approach to anchor tissue engineered cartilage in joint defects. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1743 / 1749

页数：7

共 20 条

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