Efficient construction of a doubly functionalized trisoxazole derivative relevant to the synthesis of the novel telomerase inhibitor telomestatin and its analogues

被引：20

作者：

Chattopadhyay, SK ^{[1
]}

Biswas, S ^{[1
]}

Pal, BK ^{[1
]}

机构：

[1] Univ Kalyani, Dept Chem, Kalyani 741235, W Bengal, India

来源：

SYNTHESIS-STUTTGART | 2006年 / 08期

关键词：

heterocycles; chiral pool; oxidations; peptides; oxazoles;

D O I：

10.1055/s-2006-926415

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

All efficient construction of a suitably functionalized trisoxazole derivative related to telomestatin was developed from L-serine, which involved three sequential oxazoline cyclization-oxidation steps in ail overall yield of 11% in a linear sequence of twelve steps.

引用

页码：1289 / 1294

页数：6

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