The effects of subdural haematoma on spatial learning in the rat

被引：8

作者：

Eijkenboom, M ^{[1
]}

Gerlach, I ^{[1
]}

Van der Staay, FJ ^{[1
]}

机构：

[1] Bayer AG, CNS Res, D-5600 Wuppertal, Germany

来源：

NEUROSCIENCE | 1999年 / 94卷 / 02期

关键词：

Morris water maze; rat; recovery of function; sensorimotor functioning; subdural haematoma; traumatic brain injury;

D O I：

10.1016/S0306-4522(99)00332-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although memory deficits are one of the most persistent consequences of human subdural haematoma, cognitive functioning has hardly been investigated in the rat subdural haematoma model. In the present study, the effects on spatial learning of right- and left-sided unilateral subdural haematoma and of bilateral subdural haematoma induced above the sensorimotor cortical areas were evaluated. Spatial learning was assessed by standard acquisition in the Morris water escape task (five sessions). Additional issues addressed were sensorimotor functioning (footprint analysis), recovery of cognitive functioning (tested by an overtraining and a reversal training) and replicability of induced cognitive deficits. Following unilateral subdural haematoma surgery, hardly any impairments in the Morris water escape task were observed: rats with a unilateral right-sided subdural haematoma showed very mild, transient deficits, whereas rats with left-sided subdural haematoma were indistinguishable from controls. Bilateral subdural haematoma surgery led to a clear, although transient, performance deficit. We conclude that animals with bilateral subdural haematoma may provide a promising cognitive deficit model for investigating recovery of function. (C) 1999 IBRO. Published by Elsevier Science Ltd.

引用

页码：373 / 388

页数：16

共 53 条

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