AGC protein kinase phosphorylation and protein kinase C

被引：23

作者：

Parker, PJ ^{[1
]}

Parkinson, SJ ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Prot Phosphyorylat Lab, London WC2A 3PX, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷

关键词：

autophosphorylation; input/signal; permissive; phosphoinositide; signal transduction;

D O I：

10.1042/0300-5127:0290860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events? For the downstream kinases (substrates) described here, it would appear that specificity is determined by substrate-directed events that are permissive for phosphorylation. There are also distinctions relating to the turnover of these phosphorylations providing a further element of specificity.

引用

页码：860 / 863

页数：4

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