A Pivotal Phase 2 Trial of Ponatinib in Patients with Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph plus ALL) Resistant or Intolerant to Dasatinib or Nilotinib, or with the T315I BCR-ABL Mutation: 12-Month Follow-up of the PACE Trial

被引：23

作者：

Cortes, Jorge E. ^{[1
]}

Kim, Dong-Wook ^{[2
]}

Pinilla-Ibarz, Javier ^{[3
]}

le Coutre, Philipp ^{[4
]}

Paquette, Ron ^{[5
]}

Chuah, Charles ^{[6
]}

Nicolini, Franck E. ^{[7
]}

Apperley, Jane ^{[8
]}

Khoury, H. Jean ^{[9
]}

Talpaz, Moshe ^{[10
]}

DiPersio, John F. ^{[11
]}

DeAngelo, Daniel J. ^{[12
]}

Abruzzese, Elisabetta ^{[13
]}

Rea, Delphine ^{[14
]}

Baccarani, Michele ^{[15
]}

Muller, Martin C. ^{[16
]}

Gambacorti-Passerini, Carlo ^{[17
,18
]}

Wong, Stephane ^{[19
]}

Lustgarten, Stephanie ^{[20
]}

Rivera, Victor M. ^{[20
]}

Clarkson, Tim ^{[20
]}

Turner, Christopher D. ^{[20
]}

Haluska, Frank G. ^{[20
]}

Guilhot, Francois ^{[21
]}

Deininger, Michael W. ^{[22
]}

Hochhaus, Andreas ^{[23
]}

Hughes, Timothy ^{[24
]}

Goldman, John M. ^{[25
]}

Shah, Neil ^{[26
]}

Kantarjian, Hagop M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[2] Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea

[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[4] Charite, D-13353 Berlin, Germany

[5] Univ Calif Los Angeles, Ronald Reagan UCLA Med Ctr, Los Angeles, CA USA

[6] Singapore Gen Hosp, Duke NUS Grad Med Sch, Singapore, Singapore

[7] Ctr Hosp Lyon Sud, F-69310 Pierre Benite, France

[8] Univ London Imperial Coll Sci Technol & Med, Dept Haematol, Hammersmith Hosp, London, England

[9] Emory Winship Canc Inst, Atlanta, GA USA

[10] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[11] Washington Univ, Sch Med, Div Med Oncol, St Louis, MO USA

[12] Dana Farber Canc Inst, Boston, MA 02115 USA

[13] Osped S Eugenio, Rome, Italy

[14] Hop St Louis, Dept Hematol, Paris, France

[15] Univ Bologna, Dept Hematol & Med Oncol, Bologna, Italy

[16] Univ Med Mannheim, Med Klin 3, Mannheim, Germany

[17] Univ Milano Bicocca, Dept Hematol, Monza, Italy

[18] S Gerardo Hosp, Monza, Italy

[19] MolecularMD Corp, Portland, OR USA

[20] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

[21] CHU Poitiers, INSERM, CIC 0802, Poitiers, France

[22] Univ Utah, Div Hematol & Hematol Malignancies, Huntsman Canc Inst, Salt Lake City, UT USA

[23] Univ Klinikum Jena, Jena, Germany

[24] Inst Med & Vet Sci, Adelaide, SA 5000, Australia

[25] Univ London Imperial Coll Sci Technol & Med, Dept Hematol, London, England

[26] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

BLOOD | 2012年 / 120卷 / 21期

关键词：

D O I：

10.1182/blood.V120.21.163.163

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

163

引用

页数：3