Investigation of sources of variance which contribute to NIR-spectroscopic measurement of pharmaceutical formulations

被引：10

作者：

Candolfi, A

Massart, DL

Heuerding, S

机构：

[1] FREE UNIV BRUSSELS,INST PHARMACEUT,CHEMOAC,B-1090 BRUSSELS,BELGIUM

[2] SANDOZ PHARMA LTD,PHARMACEUT DEV,CH-4002 BASEL,SWITZERLAND

来源：

ANALYTICA CHIMICA ACTA | 1997年 / 345卷 / 1-3期

关键词：

NIR; ANOVA; PCA; tablets; capsules;

D O I：

10.1016/S0003-2670(97)00059-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The goal of this study is to improve MR-spectroscopic measurement of pharmaceutical formulations. The variance contributions of the following factors to the MR-measurement of tablets, hard and soft gelatine capsules are estimated: measurement repeatability, positioning, time, different samples of one batch and different batches. The data analysis is performed on the one hand with PCA (Principal Component Analysis) as a display method and on the other hand numerically with a nested ANOVA design.

引用

页码：185 / 196

页数：12

共 20 条

[1] IDENTIFICATION OF TABLET FORMULATIONS INSIDE BLISTER PACKAGES BY NEAR-INFRARED SPECTROSCOPY [J].