SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

被引：1090

作者：

Johnson, Andrew D. ^{[3
,4
]}

Handsaker, Robert E. ^{[1
,2
]}

Pulit, Sara L. ^{[5
,6
]}

Nizzari, Marcia M. ^{[1
,2
]}

O'Donnell, Christopher J. ^{[3
,4
,7
]}

de Bakker, Paul I. W. ^{[1
,2
,5
,6
]}

机构：

[1] MIT, Broad Inst, Cambridge, MA 02142 USA

[2] Harvard Univ, Cambridge, MA 02142 USA

[3] NHLBI, Framingham Heart Study, NIH, Framingham, MA 01702 USA

[4] Boston Univ, Sch Med, Framingham, MA 01702 USA

[5] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02215 USA

[6] Harvard Univ, Sch Med, Partners HealthCare Ctr Genet & Genom, Boston, MA 02215 USA

[7] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

来源：

BIOINFORMATICS | 2008年 / 24卷 / 24期

关键词：

D O I：

10.1093/bioinformatics/btn564

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).

引用

页码：2938 / 2939

页数：2

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