Tribal and geographical variations of lupus in the Sultanate of Oman: a hospital-based study

被引:6
作者
Al Maini, MH
El-Ageb, EN
Al-Shukaily, AK
Al-Wahaibi, S
Richens, ER
机构
[1] Sultan Qaboos Univ, Coll Med, Dept Med, Muscat 123, Oman
[2] Sultan Qaboos Univ, Coll Med, Dept Immunol, Muscat 123, Oman
[3] Minist Hlth, Dept Environm Hlth & Malaria Eradicat, Muscat 113, Oman
关键词
systemic lupus erythematosus; APL antibodies; Omani patients; clinical presentation; tribal differences;
D O I
10.1007/s00296-001-0151-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% confidence interval [CI], -35.6, -16.4, and -2.31 and -38.05 to -33.06, -19.49 to -13.3, and -4.1 to -0.6, respectively). The OGA have higher levels of IgG isotype APL antibodies than OAP, both anticardiolipin (ACA) (t = 1.75, P = 1.04) and anti-beta(2)glycoprotein I (proportional tobeta(2)GPI) (t = 3.64, P = 0.004) antibodies, while OAP have higher levels of ACAs, IgM isotype (t = 2.86, P = 0.0024), than OGA. Antiphospholipid (APL) antibodies associate differently with clinical symptoms, both within OAP and between OAP and OGA. Patients from Dakiliyah have a higher risk of joint disease than those from Muscat (relative risk ratio 5.0, 95% CI 1.3 18.3). Differences in symptomatology suggest variations in genetic linkages to human systemic lupus erythematosus.
引用
收藏
页码:141 / 145
页数:5
相关论文
共 29 条
[1]   Systemic lupus erythematosus in Kuwait - hospital based study [J].
Al-Jarallah, K ;
Al-Awadi, A ;
Siddiqui, H ;
Al-Salim, I ;
Shehab, D ;
Umamaheswaran, I ;
Gaurer, S ;
Al-Saied, K ;
Kumar, R ;
Malaviya, AN .
LUPUS, 1998, 7 (07) :434-438
[2]   SYSTEMIC LUPUS-ERYTHEMATOSUS IN SAUDI PATIENTS [J].
ALBALLA, SR .
CLINICAL RHEUMATOLOGY, 1995, 14 (03) :342-346
[3]  
Alekberova Z. S., 2001, Lupus, V10, pS82
[4]   Serological characteristics of systemic lupus erythematosus from a hospital-based rheumatology clinic in Kuwait [J].
AlMekaimi, A ;
Malaviya, AN ;
Serebour, F ;
Umamaheswaran, I ;
Kumar, R ;
AlSaeid, K ;
Sharma, PN .
LUPUS, 1997, 6 (08) :668-674
[5]  
ALNAHDI MS, 1987, TROP GEOGR MED, V39, P187
[6]  
ARNETT FC, 1992, RHEUM DIS CLIN N AM, V18, P865
[7]   ANTICARDIOLIPIN ANTIBODIES - CLINICAL ASSOCIATIONS [J].
ASHERSON, RA ;
HARRIS, EN .
POSTGRADUATE MEDICAL JOURNAL, 1986, 62 (734) :1081-1087
[8]  
BATCHELOR JR, 1993, BR J RHEUMATOL, V32, P865
[9]   DERIVATION OF THE SLEDAI - A DISEASE-ACTIVITY INDEX FOR LUPUS PATIENTS [J].
BOMBARDIER, C ;
GLADMAN, DD ;
UROWITZ, MB ;
CARON, D ;
CHANG, CH .
ARTHRITIS AND RHEUMATISM, 1992, 35 (06) :630-640
[10]  
Cooper GS, 1998, ARTHRITIS RHEUM, V41, P1714, DOI 10.1002/1529-0131(199810)41:10<1714::AID-ART3>3.3.CO