Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease

被引：82

作者：

Praprotnik, D

Smith, MA

Richey, PL

Vinters, HV

Perry, G

机构：

[1] CASE WESTERN RESERVE UNIV,INST PATHOL,DIV NEUROPATHOL,CLEVELAND,OH 44106

[2] UNIV CALIF LOS ANGELES,MED CTR,DEPT PATHOL & LAB MED,LOS ANGELES,CA 90024

来源：

ACTA NEUROPATHOLOGICA | 1996年 / 91卷 / 03期

关键词：

amyloid-beta; beta-protein precursor; cytoskeleton; neurofilaments; axonal transport;

D O I：

10.1007/s004010050420

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments.

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收藏

页码：226 / 235

页数：10

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