New synthesis of 3-aryl-N-n-propyl-piperidines

被引：24

作者：

Chang, MY

Chen, ST ^{[1
]}

Chang, NC

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON | 2002年 / 58卷 / 18期

关键词：

formal [3+3] cycloaddition reaction; alpha-sulfonyl acetamide; 3-aryl-N-n-propyl-piperidines; preclamol;

D O I：

10.1016/S0040-4020(02)00282-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3 -aryl-N-n-propyl-piperidines is described in six steps starting from a-sulfonyl acetamide via the formal [3+3] cycloaddition reaction of the latter into glutarimide. The pathway involves an efficient cycloaddition and regioselective reduction, and yields useful building blocks for heterocyclic chemistry. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3623 / 3628

页数：6

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