Androgen-regulated gene expression in prostate cancer

被引:68
作者
Trapman, J
Cleutjens, KBJM
机构
[1] Department of Pathology, Erasmus University, 3000 DR Rotterdam
关键词
androgen receptor; prostate cancer; prostate development;
D O I
10.1006/scbi.1997.0050
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Androgen-regulated gene expression is mediated by the ligand-activated androgen receptor. Androgen receptor target genes contain in the regulatory regions one or more androgen response elements. Development of the male urogenital tract, including the prostate, depends on an activated androgen receptor Similarly, growth of the majority of prostate cancers is androgen-dependent. Therefore, endocrine therapy, aimed at inhibition of androgen receptor functioning, has been applied for many years. However during therapy, apparently androgen receptor independent cancers continue to grow. In general, these tumors still express the androgen receptor, suggesting a functional role of the androgen receptor In a proportion of late stage prostate tumors, mutations and amplification of the androgen receptor gene have been found. Additionally, it has been hypothesized that ligand-independent androgen receptor activation can be involved in hormone refractory prostate cancer.
引用
收藏
页码:29 / 36
页数:8
相关论文
共 78 条
[1]   THE STRINGENCY AND MAGNITUDE OF ANDROGEN-SPECIFIC GENE ACTIVATION ARE COMBINATORIAL FUNCTIONS OF RECEPTOR AND NONRECEPTOR BINDING-SITE SEQUENCES [J].
ADLER, AJ ;
SCHELLER, A ;
ROBINS, DM .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (10) :6326-6335
[2]   MULTIPLE COMPONENTS OF A COMPLEX ANDROGEN-DEPENDENT ENHANCER [J].
ADLER, AJ ;
SCHELLER, A ;
HOFFMAN, Y ;
ROBINS, DM .
MOLECULAR ENDOCRINOLOGY, 1991, 5 (11) :1587-1596
[3]   STEROID-HORMONE RECEPTORS - MANY ACTORS IN SEARCH OF A PLOT [J].
BEATO, M ;
HERRLICH, P ;
SCHUTZ, G .
CELL, 1995, 83 (06) :851-857
[4]   DEVELOPMENTAL PATTERN AND REGULATION BY ANDROGENS OF ANDROGEN RECEPTOR EXPRESSION IN THE UROGENITAL TRACT OF THE RAT [J].
BENTVELSEN, FM ;
BRINKMANN, AO ;
VANDERSCHOOT, P ;
VANDERLINDEN, JETM ;
VANDERKWAST, TH ;
BOERSMA, WJA ;
SCHRODER, FH ;
NIJMAN, JM .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 113 (02) :245-253
[5]   CRYSTAL-STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA [J].
BOURGUET, W ;
RUFF, M ;
CHAMBON, P ;
GRONEMEYER, H ;
MORAS, D .
NATURE, 1995, 375 (6530) :377-382
[6]   UBIQUITOUS TRANSCRIPTION FACTOR OTF-1 MEDIATES INDUCTION OF THE MMTV PROMOTER THROUGH SYNERGISTIC INTERACTION WITH HORMONE RECEPTORS [J].
BRUGGEMEIER, U ;
KALFF, M ;
FRANKE, S ;
SCHEIDEREIT, C ;
BEATO, M .
CELL, 1991, 64 (03) :565-572
[7]   MEASUREMENT OF PROSTATE-SPECIFIC ANTIGEN IN SERUM AS A SCREENING-TEST FOR PROSTATE-CANCER [J].
CATALONA, WJ ;
SMITH, DS ;
RATLIFF, TL ;
DODDS, KM ;
COPLEN, DE ;
YUAN, JJJ ;
PETROS, JA ;
ANDRIOLE, GL .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) :1156-1161
[8]   Delineation of two distinct type I activation functions in the androgen receptor amino-terminal domain [J].
Chamberlain, NL ;
Whitacre, DC ;
Miesfeld, RL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (43) :26772-26778
[9]   NUCLEAR-LOCALIZATION OF ANDROGEN RECEPTOR IN HETEROGENEOUS SAMPLES OF NORMAL, HYPERPLASTIC AND NEOPLASTIC HUMAN PROSTATE [J].
CHODAK, GW ;
KRANC, DM ;
PUY, LA ;
TAKEDA, H ;
JOHNSON, K ;
CHANG, C .
JOURNAL OF UROLOGY, 1992, 147 (03) :798-803
[10]   Reduced androgen receptor gene expression with first exon CAG repeat expansion [J].
Choong, CS ;
Kemppainen, JA ;
Zhou, ZX ;
Wilson, EM .
MOLECULAR ENDOCRINOLOGY, 1996, 10 (12) :1527-1535