共 78 条
Androgen-regulated gene expression in prostate cancer
被引:68
作者:

Trapman, J
论文数: 0 引用数: 0
h-index: 0
机构: Department of Pathology, Erasmus University, 3000 DR Rotterdam

Cleutjens, KBJM
论文数: 0 引用数: 0
h-index: 0
机构: Department of Pathology, Erasmus University, 3000 DR Rotterdam
机构:
[1] Department of Pathology, Erasmus University, 3000 DR Rotterdam
关键词:
androgen receptor;
prostate cancer;
prostate development;
D O I:
10.1006/scbi.1997.0050
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Androgen-regulated gene expression is mediated by the ligand-activated androgen receptor. Androgen receptor target genes contain in the regulatory regions one or more androgen response elements. Development of the male urogenital tract, including the prostate, depends on an activated androgen receptor Similarly, growth of the majority of prostate cancers is androgen-dependent. Therefore, endocrine therapy, aimed at inhibition of androgen receptor functioning, has been applied for many years. However during therapy, apparently androgen receptor independent cancers continue to grow. In general, these tumors still express the androgen receptor, suggesting a functional role of the androgen receptor In a proportion of late stage prostate tumors, mutations and amplification of the androgen receptor gene have been found. Additionally, it has been hypothesized that ligand-independent androgen receptor activation can be involved in hormone refractory prostate cancer.
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页码:29 / 36
页数:8
相关论文
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