Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project

被引：117

作者：

Iacobuzio-Donahue, Christine A. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, GI Liver Div, Baltimore, MD 21232 USA

来源：

GUT | 2012年 / 61卷 / 07期

关键词：

INTRAEPITHELIAL NEOPLASIA; SOMATIC MUTATIONS; HEREDITARY PANCREATITIS; GERMLINE MUTATIONS; WIDE ASSOCIATION; FANCONI-ANEMIA; HUMAN BREAST; OCCURS LATE; SUSCEPTIBILITY; RAS;

D O I：

10.1136/gut.2010.236026

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Pancreatic cancer is a disease caused by the accumulation of genetic alterations in specific genes. Elucidation of the human genome sequence, in conjunction with technical advances in the ability to perform whole exome sequencing, have provided new insight into the mutational spectra characteristic of this lethal tumour type. Most recently, exomic sequencing has been used to clarify the clonal evolution of pancreatic cancer as well as provide time estimates of pancreatic carcinogenesis, indicating that a long window of opportunity may exist for early detection of this disease while in the curative stage. Moving forward, these mutational analyses indicate potential targets for personalised diagnostic and therapeutic intervention as well as the optimal timing for intervention based on the natural history of pancreatic carcinogenesis and progression.

引用

页码：1085 / 1094

页数：10

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