Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility

被引：37

作者：

Alfirevic, A. ^{[1
]}

Pirmohamed, M. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 03期

关键词：

CAUSALITY ASSESSMENT METHOD; UNITED-STATES; GENOME-WIDE; RISK; HEPATOTOXICITY; SUSCEPTIBILITY; GENOTYPE; JAPANESE; FAILURE; ALLELES;

D O I：

10.1038/clpt.2012.107

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetic predisposition to drug-induced liver injury may be due to variation in both pharmacokinetic and pharmacodynamic pathways. Recent genome-wide association studies have identified, in the human leukocyte antigen (HLA) alleles, strong genetic factors that predispose to liver injury on exposure to any of several drugs. Although the genetic associations have provided mechanistic insights, none has been developed as a predictive test. Further work in this area, in combination with other "-omics" technologies, is needed to develop tests that are both clinically useful and cost-effective.

引用

页码：376 / 380

页数：5

共 30 条

[1] Case Definition and Phenotype Standardization in Drug-Induced Liver Injury
Aithal, G. P.
Watkins, P. B.
Andrade, R. J.
Larrey, D.
Molokhia, M.
Takikawa, H.
Hunt, C. M.
Wilke, R. A.
Avigan, M.
Kaplowitz, N.
Bjornsson, E.
Daly, A. K.
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (06) : 806 - 815
[2] Accuracy of hepatic adverse drug reaction reporting in one English health region
Aithal, GP
Rawlins, MD
Day, CP
[J]. BRITISH MEDICAL JOURNAL, 1999, 319 (7224) : 1541 - 1541
[3] Andrade Raul J, 2004, Expert Opin Drug Saf, V3, P329, DOI 10.1517/14740338.3.4.329
[4] Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese
Ariyoshi, Noritaka
Iga, Yukako
Hirata, Koji
Sato, Yasunori
Miura, Go
Ishii, Itsuko
Nagamori, Seiji
Kitada, Mitsukazu
[J]. DRUG METABOLISM AND PHARMACOKINETICS, 2010, 25 (03) : 298 - 306
[5] Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
Chen, Rui
Mias, George I.
Li-Pook-Than, Jennifer
Jiang, Lihua
Lam, Hugo Y. K.
Chen, Rong
Miriami, Elana
Karczewski, Konrad J.
Hariharan, Manoj
Dewey, Frederick E.
Cheng, Yong
Clark, Michael J.
Im, Hogune
Habegger, Lukas
Balasubramanian, Suganthi
O'Huallachain, Maeve
Dudley, Joel T.
Hillenmeyer, Sara
Haraksingh, Rajini
Sharon, Donald
Euskirchen, Ghia
Lacroute, Phil
Bettinger, Keith
Boyle, Alan P.
Kasowski, Maya
Grubert, Fabian
Seki, Scott
Garcia, Marco
Whirl-Carrillo, Michelle
Gallardo, Mercedes
Blasco, Maria A.
Greenberg, Peter L.
Snyder, Phyllis
Klein, Teri E.
Altman, Russ B.
Butte, Atul J.
Ashley, Euan A.
Gerstein, Mark
Nadeau, Kari C.
Tang, Hua
Snyder, Michael
[J]. CELL, 2012, 148 (06) : 1293 - 1307
[6] Genetic association studies in drug-induced liver injury
Daly, Ann K.
Day, Christopher P.
[J]. DRUG METABOLISM REVIEWS, 2012, 44 (01) : 116 - 126
[7] HLA-B☆5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Daly, Ann K.
Donaldson, Peter T.
Bhatnagar, Pallav
Shen, Yufeng
Pe'er, Itsik
Floratos, Aris
Daly, Mark J.
Goldstein, David B.
John, Sally
Nelson, Matthew R.
Graham, Julia
Park, B. Kevin
Dillon, John F.
Bernal, William
Cordell, Heather J.
Pirmohamed, Munir
Aithal, Guruprasad P.
Day, Christopher P.
[J]. NATURE GENETICS, 2009, 41 (07) : 816 - U71
[8] Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury
Donaldson, Peter T.
Daly, Ann K.
Henderson, Jill
Graham, Julia
Pirmohamed, Munir
Bernal, William
Day, Christopher P.
Aithal, Guruprasad P.
[J]. JOURNAL OF HEPATOLOGY, 2010, 53 (06) : 1049 - 1053
[9] T cell involvement in cutaneous drug eruptions
Hari, Y
Frutig-Schnyder, K
Hurni, M
Yawalkar, N
Zanni, MP
Schnyder, B
Kappeler, A
Von Greyerz, S
Braathen, LR
Pichler, WJ
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (09) : 1398 - 1408
[10] Mammography Screening: A New Estimate of Number Needed to Screen to Prevent One Breast Cancer Death
Hendrick, R. Edward
Helvie, Mark A.
[J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 2012, 198 (03) : 723 - 728

← 1 2 3 →