The challenge of inhibiting alloreactive T-cell memory

被引：57

作者：

Valujskikh, A ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Cleveland, OH 44106 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2006年 / 6卷 / 04期

关键词：

co-stimulation; immunosuppression; T cells;

D O I：

10.1111/j.1600-6143.2005.01215.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Memory T cells specific for donor antigens present a unique challenge in transplantation. In addition to expressing rapid and robust immune responses to a transplanted organ, memory T cells may be resistant to the effects of currently used graft-prolonging therapies. The increasing recognition that alloreactive memory T cells participate in transplant rejection is driving new lines of research focusing on understanding the immunobiology of alloreactive memory T cells and on designing novel therapies to specifically target memory T cells. The purpose of this review is to summarize the effects of existing immunosuppressive drugs and costimulatory blockade on functions of alloreactive memory T cells that undermine allograft survival.

引用

收藏

页码：647 / 651

页数：5

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