Multicenter study of in vitro susceptibility of the Bacteroides fragilis group, 1995 to 1996, with comparison of resistance trends from 1990 to 1996

被引:76
作者
Snydman, DR
Jacobus, NV
McDermott, LA
Supran, S
Cuchural, GJ
Finegold, S
Harrell, L
Hecht, DW
Iannini, P
Jenkins, S
Pierson, C
Rihs, J
Gorbach, SL
机构
[1] Tufts Univ, New England Med Ctr, Sch Med, Dept Med, Boston, MA 02111 USA
[2] Tufts Univ, New England Med Ctr, Sch Med, Dept Pathol, Boston, MA 02111 USA
[3] Tufts Univ, New England Med Ctr, Sch Med, Dept Community Hlth, Boston, MA 02111 USA
[4] Danbury Hosp, Danbury, CT USA
[5] Duke Univ, Med Ctr, Durham, NC USA
[6] Univ Florida, Jacksonville, FL USA
[7] Loyola Univ, Med Ctr, Maywood, IL 60153 USA
[8] Univ Michigan, Med Ctr, Ann Arbor, MI USA
[9] Pittsburgh Vet Adm Med Ctr, Pittsburgh, PA USA
[10] Wadsworth Vet Adm Hosp, Los Angeles, CA USA
关键词
D O I
10.1128/AAC.43.10.2417
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Antimicrobial resistance, including plasmid mediated resistance, among the species of the Bacteroides fragilis group is well documented. An analysis of the in vitro susceptibility of B. fragilis group species referred between 1995 and 1996 as well as during a 7-year (1990 to 1996), prospective, multicenter sun ey of over 4,000 clinical isolates of B. fragilis group species was undertaken to review trends in the percent resistance to and geometric mean MICs of the antibiotics tested. There was a trend toward a decrease in the geometric mean MICs of most beta-lactam antibiotics, while the percent resistance to most agents was less affected. Within the species B. fragilis, the geometric mean MICs showed significant (P < 0.05) decreases for piperacillin-tazobactam, ticarcillin-clavulanate, piperacillin, ticarcillin, ceftizoxime, cefotetan, and cefmetazole; a significant increase was observed for clindamycin and cefoxitin. For the non-B. fragilis species, a significant decrease in the geometric mean MICs was observed for meropenem, ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, ticarcillin, ceftizoxime, and cefmetazole; a significant increase was observed for cefoxitin, Significant increases in percent resistance were observed within the B. fragilis strains for ticarcillin and ceftizoxime and within the non-B. fragilis isolates for cefotetan, Significant increases in percent resistance among all B. fragilis group species were observed for clindamycin, while imipenem showed no significant change in resistance trends. The trend analysis for trovafloxacin was limited to 3 years, since the quinolone was tested only in 1994, 1995, and 1996, During the 7 Sears analyzed, there was no resistance to metronidazole or chloramphenicol observed. The data demonstrate that resistance among the B. fragilis group species has decreased in the past several years, the major exception being clindamycin. The majority of the resistance decrease has been for the p-lactams in B. fragilis, compared to other species. The reasons for these changes are not readily apparent.
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页码:2417 / 2422
页数:6
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