A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola steph

被引：27

作者：

Lou, HX ^{[1
]}

Li, GY ^{[1
]}

Wang, FQ ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharm, Dept Nat Prod Chem, Shandong 250012, Jinan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2002年 / 4卷 / 02期

关键词：

Hepaticae; liverworts; Frullania muscicola; diterpenoid; bibenzyls; flavonoids; cytotoxic; anti-fungi;

D O I：

10.1080/10286020290027353

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel ent-labdane type diterpenoid, muscicolone (1), as well as two bibenzyls (2, 3) and four flavonoids (4-7) were isolated from the liverwort Frullania muscicola Steph, Their structures were established by analysis of the spectral data of IR, UV, 1D-, 2D-NMR, and ORD. The stereostructure of 1 was confirmed by X-ray crystallographic analysis. Bioassay experiments showed that compound 3 and 4 have potent inhibitory effects against some fungi while 1 showed cytotoxic effects to some human tumor cells.

引用

页码：87 / 94

页数：8

共 14 条

[1] CHEMOSYSTEMATICS OF BRYOPHYTES .13. TERPENOIDS AND BIBENZYLS FROM SOME NEW-ZEALAND LIVERWORTS [J].

ASAKAWA, Y ;

CAMPBELL, EO .

PHYTOCHEMISTRY, 1982, 21 (11) :2663-2667

[2] BIBENZYL DERIVATIVES FROM FRULLANIA SPECIES [J].

ASAKAWA, Y ;

MATSUDA, R ;

CHEMINAT, A .

PHYTOCHEMISTRY, 1987, 26 (04) :1117-1122

[3]

Asakawa Y., 1995, Progress in the Chemistry of Organic Natural Products, V65, P1, DOI 10.1007/978-3-7091-6896-7_1

[4]

ASKAWA Y, 1987, PHYTOCHEMISTRY, V26, P1023

[5]

DJERASSI C, 1964, P CHEM SOC LONDON, P314

[6]

KRAUT L, 1995, Z NATURFORSCH C, V50, P345

[7] ACYLATED FLAVONE AND GLYCEROL GLUCOSIDES FROM 2 FRULLANIA SPECIES [J].

KRAUT, L ;

MUES, R ;

SIMSIM, M .

PHYTOCHEMISTRY, 1993, 34 (01) :211-218

[8] SESQUITERPENE LACTONES AND 3-BENZYLPHTHALIDES FROM FRULLANIA-MUSCICOLA [J].

KRAUT, L ;

MUES, R ;

SIMSIM, M .

PHYTOCHEMISTRY, 1994, 37 (05) :1337-1346

[9] AN ANTIFUNGAL BIBENZYL FROM THE NEW-ZEALAND LIVERWORT, PLAGIOCHILA-STEPHENSONIANA - BIOACTIVITY-DIRECTED ISOLATION, SYNTHESIS, AND ANALYSIS [J].

LORIMER, SD ;

PERRY, NB ;

TANGNEY, RS .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (09) :1444-1450

[10] REARRANGED ENT-EUDESMANE-TYPE AND ENT-EREMOPHILANE-TYPE SESQUITERPENOIDS FROM THE LIVERWORT FRULLANIA-DILATATA [J].

NAGASHIMA, F ;

TAKAOKA, S ;

HUNECK, S ;

ASAKAWA, Y .

PHYTOCHEMISTRY, 1994, 37 (05) :1317-1321

← 1 2 →