Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

被引：132

作者：

Ludolph, A. C. ^{[1
]}

Kassubek, J. ^{[1
]}

Landwehrmeyer, B. G. ^{[1
]}

Mandelkow, E. ^{[2
]}

Mandelkow, E. -M. ^{[2
]}

Burn, D. J. ^{[3
]}

Caparros-Lefebvre, D. ^{[4
]}

Frey, K. A. ^{[5
]}

de Yebenes, J. G. ^{[6
]}

Gasser, T. ^{[7
]}

Heutink, P. ^{[8
]}

Hoglinger, G. ^{[9
]}

Jamrozik, Z. ^{[10
]}

Jellinger, K. A. ^{[11
]}

Kazantsev, A. ^{[12
]}

Kretzschmar, H. ^{[13
]}

Lang, A. E. ^{[14
]}

Litvan, I. ^{[15
]}

Lucas, J. J. ^{[16
,17
]}

McGeer, P. L. ^{[18
]}

Melquist, S. ^{[19
]}

Oertel, W. ^{[8
]}

Otto, M. ^{[1
]}

Paviour, D. ^{[20
]}

Reum, T. ^{[21
]}

Saint-Raymond, A. ^{[22
]}

Steele, J. C.

Tolnay, M. ^{[23
]}

Tumani, H. ^{[1
]}

van Swieten, J. C. ^{[24
]}

Vanier, M. T. ^{[25
]}

Vonsattel, J. -P. ^{[26
]}

Wagner, S. ^{[27
]}

Wszolek, Z. K. ^{[28
]}

机构：

[1] Univ Ulm, Dept Neurol, D-7900 Ulm, Germany

[2] DESY, Max Planck Unit Struct Mol Biol, D-2000 Hamburg, Germany

[3] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne, Tyne & Wear, England

[4] Ctr Hosp Valenciennes, Valenciennes, France

[5] Univ Michigan, Med Ctr, Ann Arbor, MI USA

[6] Hosp Ramon & Cajal, E-28034 Madrid, Spain

[7] Univ Klinikum Tubingen, Zentrum Neurol, Tubingen, Germany

[8] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet & Anthropogenet, Amsterdam, Netherlands

[9] Univ Marburg, Marburg, Germany

[10] Med Univ Warsaw, Warsaw, Poland

[11] Inst Clin Neurobiol, Vienna, Austria

[12] Harvard Univ, Sch Med, Massachusetts Gen Hosp, MIND, Charlestown, MA USA

[13] Univ Munich, Inst Neuropathol, BrainNet German Brain Bank, D-8000 Munich, Germany

[14] Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada

[15] Univ Louisville, Sch Med, Dept Neurol, Louisville, KY 40292 USA

[16] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[17] CiberNed, Madrid, Spain

[18] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V5Z 1M9, Canada

[19] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[20] Natl Hosp Neurol, Dementia Res Ctr, London, England

[21] Bundesinst Arzneimittel & Medizinprod, Wissensch Serv Klin Prufungen, Bonn, Germany

[22] EMEA, Sci Advice & Orphan Drugs Sector, London, England

[23] Univ Basel, Inst Pathol, Basel, Switzerland

[24] Erasmus MC, Dept Neurol, Univ Rotterdam Hosp, Rotterdam, Netherlands

[25] Laennec Med Sch, INSERM, U820, Lyon, France

[26] Columbia Univ, Babies Hosp, New York Brain Bank, New York, NY USA

[27] Deutsch PSP Gesell eV PSP Germany, Leipzig, Germany

[28] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2009年 / 16卷 / 03期

关键词：

corticobasal degeneration; frontotemporal dementia with parkinsonism linked to chromosome 17; microtubule-associated protein tau; multiple system atrophy; Parkinson disease; parkinsonism; progressive supranuclear palsy; tauopathies; PROGRESSIVE SUPRANUCLEAR PALSY; MITOCHONDRIAL COMPLEX-I; GLYCOGEN-SYNTHASE KINASE-3; TRANSGENIC MICE; TAU-PROTEIN; MOUSE MODEL; FRONTOTEMPORAL DEMENTIA; ATYPICAL PARKINSONISM; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES;

D O I：

10.1111/j.1468-1331.2008.02513.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann-Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson-dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.

引用

页码：297 / 309

页数：13

共 84 条

[1] Further evidence for mitochondrial dysfunction in progressive supranuclear palsy [J].