The meaning of gene positioning

被引：178

作者：

Takizawa, Takumi ^{[1
]}

Meaburn, Karen J. ^{[1
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2008年 / 135卷 / 01期

关键词：

D O I：

10.1016/j.cell.2008.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is no doubt that genomes are organized nonrandomly in the nucleus of higher eukaryotes. But what is the functional relevance of this nonrandomness? In this Essay, we explore the biological meaning of spatial gene positioning by examining the functional link between the activity of a gene and its radial position in the nucleus.

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页码：9 / 13

页数：5

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