Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus

被引：223

作者：

Dong, YZ

Zhao, XL

Domagala, J

Drlica, K

机构：

[1] Publ Hlth Res Inst City New York Inc, New York, NY 10016 USA

[2] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Ann Arbor, MI 48105 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 07期

关键词：

D O I：

10.1128/AAC.43.7.1756

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp drop. The plateau region correlated,vith the presence of first-step resistant mutants. Mutants were not recovered at concentrations above those required for the second sharp drop, thereby defining a mutant prevention concentration (MPC). A C-8-methoxy group lowered the MPC for an N-1-cyclopropyl fluoroquinolone.

引用

页码：1756 / 1758

页数：3

共 15 条

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