Contribution of interleukin-1 to Th1- and Th2-dependent variants of chronic graft-versus-host reaction

被引：3

作者：

Kozlov, VA ^{[1
]}

Safronova, IV ^{[1
]}

Kudaeva, OT ^{[1
]}

Kolesnikova, OP ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Div, Res Inst Clin Immunol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 02期

关键词：

chronic graft-versus-host reaction; interleukin-1; glomerulonephritis;

D O I：

10.1023/A:1013038130199

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Semiallogenic transfer of lymphoid cells from parental DBA/2 strain to (C57Bl/6xDBA/2)F, hybrids induces two variants of chronic graft-versus-host reaction with predominant activation of donor Th1 or Th2 cells [2] in genetically homologous recipients: first, severe inhibition of the humoral immune response, or second, autoimmune disease (lupus nephritis) against the background of suppressed cell and humoral immunity. These variants of chronic graft-versus-host reaction are characterized by different changes in interleukin-1 level.

引用

页码：769 / 771

页数：3

共 13 条

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