pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia

被引：56

作者：

Marttila, HJ

Marjamäki, M

Vyshnevskaya, E

Vyshnevskiy, BI

Otten, TF

Vasilyef, AV

Viljanen, MK

机构：

[1] Natl Publ Hlth Inst, Mycobacterial Reference Lab, Turku 20520, Finland

[2] Res Inst Phthisiopulm, St Petersburg 193130, Russia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 07期

关键词：

D O I：

10.1128/AAC.43.7.1764

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thirty-six pyrazinamide-resistant and eight pyrazinamide-susceptible Mycobacterium tuberculosis isolates from Russia were analyzed for their pncA mutations. Thirty-one (86.1%) of the resistant isolates had a mutation either in pncA or upstream of the gene. Twenty of the 23 different mutations found in this study had not been described earlier. pncA genotype correlated well with pyrazinamidase activity and BACTEC 460 susceptibility test results.

引用

页码：1764 / 1766

页数：3

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