Synthesis and biological evaluation of a fluorinated analog of the beta-adrenergic blocking agent, metoprolol

被引：9

作者：

Iseki, K ^{[1
]}

Oishi, S ^{[1
]}

Sasai, H ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(97)00207-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1273 / 1274

页数：2

共 13 条

[1]

BLACK JW, 1962, LANCET, V2, P311

[2]

BLINKS JOHN R., 1964, ARCHIV EXP PATHOL PHARMAKOL [NAUNYN SCHMIEDEBERGS], V248, P73

[3]

Filler R., 1993, ORGANOFLUORINE COMPO

[4]

Filler R., 1982, BIOMEDICAL ASPECTS F

[5] FLUORO KETONE INHIBITORS OF HYDROLYTIC ENZYMES [J].

GELB, MH ;

SVAREN, JP ;

ABELES, RH .

BIOCHEMISTRY, 1985, 24 (08) :1813-1817

[6] FLUORO KETONE PHOSPHOLIPID ANALOGS - NEW INHIBITORS OF PHOSPHOLIPASE-A2 [J].

GELB, MH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (11) :3146-3147

[7] Reversal of stereoselectivity in the Evans aldol reaction of alpha,alpha-difluoro and alpha,alpha,alpha-trifluoro carbonyl compounds [J].

Iseki, K ;

Oishi, S ;

Kobayashi, Y .

TETRAHEDRON, 1996, 52 (01) :71-84

[8] Catalytic asymmetric nitroaldol reaction of alpha,alpha-difluoro aldehydes mediated by rare earth lithium BINOL complexes [J].

Iseki, K ;

Oishi, S ;

Sasai, H ;

Shibasaki, M .

TETRAHEDRON LETTERS, 1996, 37 (50) :9081-9084

[9]

KIRK KL, 1995, FLUORINE CONTAINING, P343

[10] ACTIVATED KETONE BASED INHIBITORS OF HUMAN RENIN [J].

PATEL, DV ;

RIELLYGAUVIN, K ;

RYONO, DE ;

FREE, CA ;

SMITH, SA ;

PETRILLO, EW .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2431-2447

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