Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

被引：123

作者：

Liu, Pengyuan

Vikis, Haris G.

Wang, Daolong

Lu, Yan

Wang, Yian

Schwartz, Ann G. ^{[3
]}

Pinney, Susan M. ^{[4
]}

Yang, Ping ^{[5
]}

de Andrade, Mariza ^{[5
]}

Petersen, Gloria M. ^{[5
]}

Wiest, Jonathan S. ^{[6
]}

Fain, Pamela R. ^{[7
]}

Gazdar, Adi ^{[8
]}

Gaba, Colette ^{[9
]}

Rothschild, Henry ^{[10
]}

Mandal, Diptasri ^{[10
]}

Coons, Teresa ^{[11
]}

Lee, Juwon

Kupert, Elena

Seminara, Daniela ^{[5
]}

Minna, John ^{[8
]}

Bailey-Wilson, Joan E. ^{[12
]}

Wu, Xifeng ^{[13
]}

Spitz, Margaret R. ^{[13
]}

Eisen, Timothy ^{[14
]}

Houlston, Richard S. ^{[15
]}

Amos, Christopher I. ^{[13
]}

Anderson, Marshall W.

You, Ming ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Surg, St Louis, MO 63110 USA

[2] Washington Univ, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA

[3] Karmanos Canc Inst, Detroit, MI USA

[4] Univ Cincinnati, Cincinnati, OH USA

[5] Mayo Clin, Rochester, MN USA

[6] NCI, Bethesda, MD 20892 USA

[7] Univ Colorado, Denver, CO 80202 USA

[8] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[9] Univ Toledo, Coll Med, Toledo, OH 43606 USA

[10] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA

[11] Saccomanno Res Inst, Grand Junction, CO USA

[12] NHGRI, Baltimore, MD USA

[13] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[14] Univ Cambridge, Dept Oncol, Cambridge CB2 2RE, England

[15] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2008年 / 100卷 / 18期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/jnci/djn268

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

引用

页码：1326 / 1330

页数：5

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