RETRACTED: Effective dose of granisetron for preventing postoperative emesis in children (Retracted article. See vol. 59, pg. 1170, 2012)

Purpose: This study Was to identify the minimum effective dose of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, to prevent postoperative vomiting in chil dren who have undergone strabismus repair, tonsillectomy or tonsillectomy with adenoidectomy. Methods: in a randomized double-blind fashion, 80 healthy children aged 4-10 yr were assigned to receive either placebo (saline) or granisetron in a dose of 20 40 or SO mu g . kg(-1) iv immediately following the induction of anaesthesia. All subjects received a standardized anaesthetic, which consisted of sevoflurane in nitrous oxide and oxygen. Rescue antiemetics were administered if two or more episodes of vomiting occurred. Postoperative pain was treated with acetaminophene pr or pentazocine iv, During the first 24 hr after anaesthesia, the frequencies of retching and vomiting were recorded in a standardized fashion by nursing staff while subjects were in a hospital. Results: There were no differences among four treatment groups With regard to subject characteristics, surgical procedures, anaesthetic and postoperative management or adverse effects. The frequencies of these symptoms Were as follows: 65%, 60%, 20% and 15% after administration of placebo, granisetron 20, 40 or 80 mu g . kg(-1). Three children who had received either placebo or granisetron 20 mu g . kg(-1) required another rescue antiemetic drug, whereas none who had received granisetron 40 or SO mu g . kg(-1) needed rescue drugs. Conclusion: Granisetron 40 mu g . kg(-1) is an effective antiemetic Sor preventing retching and vomiting following strabismus repair and tonsillectomy in children. Increasing the dose to 80 mu g . kg(-1) provided no demonstrable benefit in reducing postoperative emesis.