Sterol 22-desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism

被引：32

作者：

Kelly, SL

Lamb, DC

Kelly, DE

机构：

[1] Krebs Inst. for Biomol. Research, Dept. of Molec. Biol. and Biotech., Sheffield University

来源：

FEBS LETTERS | 1997年 / 412卷 / 01期

关键词：

D O I：

10.1016/S0014-5793(97)00785-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CYP61 was revealed in the sequencing of the yeast genome on chromosome XIII and was the last member of the CYP superfamily in yeast to be discovered. We show here that besides the housekeeping role in 22-desaturation during ergosterol biosynthesis the enzyme is also that responsible for benzo(a)pyrene metabolism/promutagen activation by yeast in genotoxicity assays. This enzyme may represent an ancestral activity for the superfamily which allowed xenobiotic metabolism for the first time. (C) 1997 Federation of European Biochemical Societies.

引用

页码：233 / 235

页数：3

共 10 条

[1]

AOYAMA Y, 1996, J BIOCH, V12, P12

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