The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

被引:150
作者
Chadwick, LR [1 ]
Pauli, GF [1 ]
Farnsworth, NR [1 ]
机构
[1] Univ Illinois, NIH, Ctr Bot Dietary Supplements Res, Coll Pharm, Chicago, IL 60612 USA
关键词
Humulus lupulus; pharmacognosy; pharmacology; estrogenic properties;
D O I
10.1016/j.phymed.2004.07.006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
As the population ages, there is an ever-increasing need for therapeutic agents that can be used safely and efficaciously to manage symptoms related to postmenopausal estrogen deficiency. Endogenous estrogens, e.g., 17 beta-estradiol, of exogenous mammalian origin, e.g., horses, have long been used to manage such symptoms. There are more than 20 different classes of phytochemicals that have demonstrated affinity for human estrogen receptors in vitro. Some studies on exogenous estrogenic substances of botanical origin (phytoestrogens), such as standardized formulations of plant extracts with in vitro and in vivo estrogenic activity from soy (Glycine max Merill.) and red clover (Trifolium pratense L.), suggest clinical efficacy. Few clinical data for phytoestrogens other than isoflavonoids are available. In an exhaustive review of the literature through 2003, only two clinical trials were identified that were designed to evaluate the effect of hops (Humulus lupulus L.) on symptoms related to menopause. Folkloric, chemical, and biological literature relating primarily to the use of hops for their estrogenic activity, and two human clinical trials, are reviewed. (c) 2005 Elsevier GmbH. All rights reserved.
引用
收藏
页码:119 / 131
页数:13
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