Characterization of the C-MYC amplicon in a case of acute myeloid leukemia with double minute chromosomes

被引：12

作者：

Crossen, PE ^{[1
]}

Savage, LM

Heaton, DC

Morrison, MJ

机构：

[1] Christchurch Hosp, Cytogenet & Mol Oncol Unit, Christchurch, New Zealand

[2] Christchurch Hosp, Dept Hematol, Christchurch, New Zealand

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 112卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(98)00260-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have characterized the double minute chromosomes in a ease of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3' and 5' of MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5' of MYC to the PVT gene located 280 kb 3' of MYC. This appears to be the largest MYC-containing amplicon in human leukemia. (C) Elsevier Science Inc., 1999. All rights reserved.

引用

页码：144 / 148

页数：5

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