Stochastic versions of the Hodgkin-Huxley equations

被引:215
作者
Fox, RF
机构
[1] School of Physics, Georgia Institute of Technology, Atlanta
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0006-3495(97)78850-7
中图分类号
Q6 [生物物理学];
学科分类号
071011 [生物物理学];
摘要
A Hodgkin-Huxley model algorithm for the numerical simulation of noise in neurons is contracted from a master equation description (cellular automoton) into a Langevin description. This reduction reduces the time required for a simulation by about two orders of magnitude. Earlier work is summarized, condensed, and made explicit to make the algorithm transparent and facilitate applications. Two approximate treatments are reported. An extension of this approach is presented that includes spatial dependence and the propagation of a noisy action potential along an axon.
引用
收藏
页码:2068 / 2074
页数:7
相关论文
共 24 条
[1]
Arnold L., 1974, Stochastic Differential Equations: Theory and Applications, DOI DOI 10.1002/ZAMM.19770570413
[2]
Single-domain/bound calcium hypothesis of transmitter release and facilitation [J].
Bertram, R ;
Sherman, A ;
Stanley, EF .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1919-1931
[3]
BERTRAM R, 1996, IN PRESS SIAM J APPL
[4]
Spontaneous action potentials due to channel fluctuations [J].
Chow, CC ;
White, JA .
BIOPHYSICAL JOURNAL, 1996, 71 (06) :3013-3021
[5]
STOCHASTIC RESONANCE WITHOUT TUNING [J].
COLLINS, JJ ;
CHOW, CC ;
IMHOFF, TT .
NATURE, 1995, 376 (6537) :236-238
[6]
APERIODIC STOCHASTIC RESONANCE IN EXCITABLE SYSTEMS [J].
COLLINS, JJ ;
CHOW, CC ;
IMHOFF, TT .
PHYSICAL REVIEW E, 1995, 52 (04) :R3321-R3324
[7]
DEFELICE LJ, 1992, J STAT PHYS, V70, P339
[8]
EMERGENT COLLECTIVE BEHAVIOR IN LARGE NUMBERS OF GLOBALLY COUPLED INDEPENDENTLY STOCHASTIC ION CHANNELS [J].
FOX, RF ;
LU, YN .
PHYSICAL REVIEW E, 1994, 49 (04) :3421-3431
[9]
2ND-ORDER ALGORITHM FOR THE NUMERICAL-INTEGRATION OF COLORED-NOISE PROBLEMS [J].
FOX, RF .
PHYSICAL REVIEW A, 1991, 43 (06) :2649-2654
[10]
Hille B., 1992, IONIC CHANNELS EXCIT