Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species .1. Production, isolation and biological activities

被引：49

作者：

Engler, M

Anke, T

Sterner, O

Brandt, U

机构：

[1] UNIV KAISERSLAUTERN,LB BIOTECHNOL,D-67663 KAISERSLAUTERN,GERMANY

[2] LUND UNIV,DEPT ORGAN CHEM 2,S-22100 LUND,SWEDEN

[3] UNIV FRANKFURT KLINIKUM,ZENTRUM BIOL CHEM,D-60590 FRANKFURT,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 04期

关键词：

D O I：

10.7164/antibiotics.50.325

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).

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页码：325 / 329

页数：5

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