Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs

被引：421

作者：

Calderon-Garciduenas, Lilian ^{[1
,2
]}

Mora-Tiscareno, Antonieta ^{[2
]}

Ontiveros, Esperanza ^{[2
]}

Gomez-Garza, Gilberto ^{[2
]}

Barragan-Mejia, Gerardo ^{[2
]}

Broadway, James ^{[3
]}

Chapman, Susan ^{[4
]}

Valencia-Salazar, Gildardo ^{[2
]}

Jewells, Valerie ^{[5
]}

Maronpot, Robert R. ^{[6
]}

Henriquez-Roldan, Carlos ^{[7
]}

Perez-Guille, Beatriz ^{[2
]}

Torres-Jardon, Ricardo ^{[8
]}

Herrit, Lou ^{[1
]}

Brooks, Diane ^{[1
]}

Osnaya-Brizuela, Norma ^{[2
]}

Monroy, Maria E. ^{[2
]}

Gonzalez-Maciel, Angelica ^{[2
]}

Reynoso-Robles, Rafael ^{[2
]}

Villarreal-Calderon, Rafael ^{[9
]}

Solt, Anna C. ^{[10
]}

Engle, Randall W. ^{[3
]}

机构：

[1] Univ Montana, Coll Hlth Profess & Biomed Sci, Ctr Struct & Funct Neurosci, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA

[2] Inst Nacl Pediat, Mexico City, DF, Mexico

[3] Georgia Inst Technol, Sch Psychol, Atlanta, GA 30332 USA

[4] Rockdale Cty Publ Sch, Conyers, GA 30012 USA

[5] Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA

[6] Expt Pathol Labs Inc, Res Triangle Pk, NC 27709 USA

[7] Univ Valparaiso, Dept Estadist, Valparaiso, Chile

[8] Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Mexico City 04510, DF, Mexico

[9] Univ Montana, Davidson Honors Coll, Missoula, MT 59812 USA

[10] Harvard Univ, S Shore Psychiat Program, Brockton, MA 02301 USA

来源：

BRAIN AND COGNITION | 2008年 / 68卷 / 02期

关键词：

Air pollution; Brain MRI; Children; Dogs; Endothelial pathology; Fluid cognition; Neuroinflammation; Particulate matter PM; Ultrafine PM; White matter hyperintense lesions WML;

D O I：

10.1016/j.bandc.2008.04.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n: 18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 beta in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow-Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：117 / 127

页数：11

共 77 条

[1] IL-1β regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program [J].

Argaw, Azeb Tadesse ;

Zhang, Yueting ;

Snyder, Brian J. ;

Zhao, Meng-Liang ;

Kopp, Natalya ;

Lee, Sunhee C. ;

Raine, Cedric S. ;

Brosnan, Celia F. ;

John, Gareth R. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (08) :5574-5584

[2] Predictors of concentrations of nitrogen dioxide, ne particulate matter, and particle constituents inside of lower socioeconomic status urban homes [J].

Baxter, Lisa K. ;

Clougherty, Jane E. ;

Laden, Francine ;

Levy, Jonathan I. .

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2007, 17 (05) :433-444

[3] 2000 Report of the AVMA Panel on Euthanasia [J].

Beaver, BV ;

Reed, W ;

Leary, S ;

McKiernan, B ;

Bain, F ;

Schultz, R ;

Bennett, BT ;

Pascoe, P ;

Shull, E ;

Cork, LC ;

Francis-Floyd, R ;

Amass, KD ;

Johnson, R ;

Schmidt, RH ;

Underwood, W ;

Thornton, GW ;

Kohn, B .

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2001, 218 (05) :669-696

[4]

Blair C, 2006, BEHAV BRAIN SCI, V29, P109

[5] Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City [J].

Bonner, JC ;

Rice, AB ;

Lindroos, PM ;

O'Brien, PO ;

Dreher, KL ;

Rosas, I ;

Alfaro-Moreno, E ;

Osornio-Vargas, AR .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (04) :672-680

[6] Monitoring of EAE onset and progression in the common marmoset monkey by sequential high-resolution 3D MRI [J].

Boretius, S ;

Schmelting, B ;

Watanabe, T ;

Merkler, D ;

Tammer, R ;

Czéh, B ;

Michaelis, T ;

Frahm, J ;

Fuchs, E .

NMR IN BIOMEDICINE, 2006, 19 (01) :41-49

[7]

BRAVO HA, 2002, URBAN AIR POLLUTION, P121

[8] CEREBRAL WHITE-MATTER LESIONS, VASCULAR RISK-FACTORS, AND COGNITIVE FUNCTION IN A POPULATION-BASED STUDY - THE ROTTERDAM STUDY [J].

BRETELER, MMB ;

VANSWIETEN, JC ;

BOTS, ML ;

GROBBEE, DE ;

CLAUS, JJ ;

VANDENHOUT, JHW ;

VANHARSKAMP, F ;

TANGHE, HLJ ;

DEJONG, PTVM ;

VANGIJN, J ;

HOFMAN, A .

NEUROLOGY, 1994, 44 (07) :1246-1252

[9] Regional white matter and neuropsychological functioning across the adult lifespan [J].

Brickman, Adam M. ;

Zimmerman, Molly E. ;

Paul, Robert H. ;

Grieve, Stuart M. ;

Tate, David F. ;

Cohen, Ronald A. ;

Williams, Leanne M. ;

Clark, C. Richard ;

Gordon, Evian .

BIOLOGICAL PSYCHIATRY, 2006, 60 (05) :444-453

[10] Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution [J].

Calderón-Garcidueñas, L ;

Reed, W ;

Maronpot, RR ;

Henríquez-Roldán, C ;

Delgado-Chavez, R ;

Calderón-Garcidueñas, A ;

Dragustinovis, I ;

Franco-Lira, M ;

Aragón-Flores, M ;

Solt, AC ;

Altenburg, M ;

Torres-Jordón, R ;

Swenberg, JA .

TOXICOLOGIC PATHOLOGY, 2004, 32 (06) :650-658

← 1 2 3 4 5 6 7 8 →