Natural killer cells: integrating diversity with function

被引：99

作者：

Cheent, Kuldeep ^{[1
]}

Khakoo, Salim I. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Med, Dept Hepatol, London W2 1PG, England

来源：

IMMUNOLOGY | 2009年 / 126卷 / 04期

关键词：

diversity; integration; KIR; NK cells; receptors; signalling; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC CLASS-I; IMMUNOGLOBULIN-LIKE RECEPTORS; VIRUS-INFECTED CELLS; RESTING NK CELLS; INHIBITORY RECEPTORS; HLA-C; ACTIVATING RECEPTORS; MISSING SELF; LIGANDS;

D O I：

10.1111/j.1365-2567.2009.03045.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The key role of natural killer cells in many aspects of the immune response is now being recognized. The last decade has seen an exponential increase in our understanding of the workings of these cells. Receptor diversity is crucial in allowing natural killer cells to respond effectively to a variety of different pathogens. This article reviews aspects of natural killer cell diversity that combine to generate populations of functional natural killer cells that exist within both the individual and throughout the population at large.

引用

页码：449 / 457

页数：9

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