Lack of association of the dopamine D4 receptor gene polymorphism with alcoholism in a Brazilian population

被引:23
作者
Roman, T [1 ]
Bau, CHD [1 ]
Almeida, S [1 ]
Hutz, MH [1 ]
机构
[1] Univ Fed Rio Grande Sul, Inst Biociencias, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil
关键词
D O I
10.1080/13556219971713
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The dopaminergic system has been implicated in alcoholism, but most of the past investigations concentrated on the dopamine D2 receptor (DRD2), with conflicting results. The dopamine D4 receptor gen (DRD4) is in the same class as DRD2, bur presents different pharmacological properties. This gene has an expressed highly variable 48 base pair (bp) tandem repeat polymorphism (VNTR), which could be of functional relevance. We screened 100 Caucasians and 100 Afro-Brazilians to determines the allele distribution of this polymorphism in a southern Brazilian population. The allele frequencies observed are significantly, different from those described in the literature except when Afro-Brazilians and African Bantus ale compared. A group of 136 male alcoholics, classified according to DSM-III-R criteria for alcohol dependence, was also ascertained. The results of the association study were negative for comparisons between white and black alcoholics and controls, and no association was disclosed wizen either subtypes of alcoholics and different aspects of this condition were considered. These results, together with those available in the literature for other ethnic groups, suggest a minor role, if any of the DRD4 gene in the susceptibility to alcoholism.
引用
收藏
页码:203 / 207
页数:5
相关论文
共 23 条
  • [1] DRD4 DOPAMINE-RECEPTOR GENOTYPE AND CSF MONOAMINE METABOLITES IN FINNISH ALCOHOLICS AND CONTROLS
    ADAMSON, MD
    KENNEDY, J
    PETRONIS, A
    DEAN, M
    VIRKKUNEN, M
    LINNOILA, M
    GOLDMAN, D
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (03): : 199 - 205
  • [2] [Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
  • [3] BABOR TF, 1992, ARCH GEN PSYCHIAT, V49, P599
  • [4] ALCOHOLISM IN BRAZIL - THE ROLE OF PERSONALITY AND SUSCEPTIBILITY TO STRESS
    BAU, CHD
    SALZANO, FM
    [J]. ADDICTION, 1995, 90 (05) : 693 - 698
  • [5] CARMICHAEL FJ, 1975, J PHARMACOL EXP THER, V193, P824
  • [6] The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
    Chang, FM
    Kidd, JR
    Livak, KJ
    Pakstis, AJ
    Kidd, KK
    [J]. HUMAN GENETICS, 1996, 98 (01) : 91 - 101
  • [7] The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: Six polymorphisms tested separately and as haplotypes
    Chang, FM
    Ko, HC
    Lu, RB
    Pakstis, AJ
    Kidd, KK
    [J]. BIOLOGICAL PSYCHIATRY, 1997, 41 (04) : 394 - 405
  • [8] NEUROGENETIC ADAPTIVE-MECHANISMS IN ALCOHOLISM
    CLONINGER, CR
    [J]. SCIENCE, 1987, 236 (4800) : 410 - 416
  • [9] DIFFERENTIAL EFFECT OF ACUTE AND CHRONIC ETHANOL ON DOPAMINE METABOLISM IN FRONTAL-CORTEX, CAUDATE-NUCLEUS AND SUBSTANTIA-NIGRA
    FADDA, F
    ARGIOLAS, A
    MELIS, MR
    SERRA, G
    GESSA, GL
    [J]. LIFE SCIENCES, 1980, 27 (11) : 979 - 986
  • [10] POLYMORPHISMS OF THE D4 DOPAMINE-RECEPTOR ALLELES IN CHRONIC-ALCOHOLISM
    GEORGE, SR
    CHENG, R
    NGUYEN, T
    ISRAEL, Y
    ODOWD, BF
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (01) : 107 - 114